| abstract |
Disclosed is a medicine for preventing sudden death of a mammal, including a human, which comprises (a) a therapeutically effective amount of a corticotropin releasing factor (CRF) antagonist and (b) a pharmaceutically acceptable carrier. The CRF antagonist may be a compound of the formula: (see above formula) (wherein A is CH, N, etc.; B is NH2 or the like; D is N, CH, etc.; E is N, CH, etc.; Y is N or CH; Z is NH, O, S, CH2, etc.; R3 is H, alkyl, etc.; R4 is H, alkyl, etc.; and R5 is a ring). |