abstract |
The present invention discloses complexes of the 53BP2 protein with proteins identified as interacting with 53BP2 (53BP2-IPs) by a yeast two hybrid assay system. The proteins which were demonstrated to interact with 53BP2 are: .beta.-tubulin, p62, hnRNP G, and three gene products, 53BP2:IP-1, 53BP2:IP-2 and 53BP2:IP-3, which are encoded (in part) by the EST R72810 sequence. Thus, the present invention discloses complexes of 53BP2 and .beta.-tubulin, p62, hnRNP G, 53BP2:IP-1, 53BP2:IP-2 and 53BP2:IP-3, and derivatives, fragments and analogs thereof. The present invention also discloses the 53BP2:IP-1, 53BP2:IP-2 and 53BP2:IP-3 genes and proteins, as well as derivatives, fragments and analogs thereof. Methodologies for screening the aforementioned complexes for efficacy in treating and/or preventing certain diseases and disorders (particularly, cancer, autoimmune disease and neurodegenerative disease) are also provided by the present invention. |