| abstract |
The present invention relates to a sphingosine kinase signalling pathway via which cellular activities such as adhesion molecule expression are achieved. By regulating the expression and activity of individual components of this pathway, these cellular activities can be modulated. The present invention also contemplates a rapid, high volume assay for detecting agents exhibiting sphingosine kinase and agents that can act as agonists and antagonists of these sphingosine kinase activity. |