| abstract |
The invention relates to novel analogues of camptothecin and particular the products corresponding to the formulas following: (+) - 5-ethyl-9,10-difluoro-5-hydroxy-4,5,13,15-tetrahydro-1H, 3H-oxepino [3 ', 4': 6, 7] indolizino [1,2-b] quinoline-3,15-dione; (+) - 1- [9-chloro-5-ethyl-5-hydroxy-10-methyl-3,15-dioxo-4,5,13 chloride, 15-tetrahydro-1H, 3H-oxepino [3 ', 4': 6.7] indolizino [1,2-b] quinolin-12-ylmethyl] -4-methylhexahydropyridinium; their application as drugs, pharmaceutical compositions enclosing them and their use for the production of medicaments antitumorals, antivirals or antiparasitics. It also concerns a new intermediary in the synthesis of the aforementioned products as well a method of preparing said intermediate. |