| abstract |
This invention provides compounds of formula (1) wherein X is a C3-C7 substituted or unsubstituted cycloalkyl, pyridinyl, pyrimidinyl or phenyl rings, R1, R3 and R4 are independently hydrogen, halogen and specified organic radicals of between 1 and 12 carbon atoms in length, and R2 is chosen from various unsaturated acyl groups. The novel compounds are useful as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases, such as polycystic kidney disease. |