http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2296070-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5128cfc84a0fb189fceb3cd240c44493 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-12002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 |
| filingDate | 1998-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65676701c01476cd2e535480391aebe5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98eef626d703f42f186ecdd11be59467 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a04251c6da879e3ab6ae49d2b4186dd8 |
| publicationDate | 2003-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2296070-C |
| titleOfInvention | Novel mapk kinase |
| abstract | Disclosed is a substantially pure MAPK (mitogen-activated protein kinase) kinase derived from a verte-brate, which is activated by a stimulus induced by TNF-.alpha. and/or by a stimulation of Fas antigen, and which in turn activates SAPK/JNK, but does not activate p38; and also disclosed is a DNA coding for the same. By the use of the novel MAPK kinase and the DNA coding for the same of the present invention, it has become possible to screen a novel substance having the capability to treat or prevent diseases resulting from an excess activation or inhibition of a MAP kinase cascade, and also to provide a diagnostic reagent for such diseases. In addition, the DNA of the present invention encoding the MAPK kinase can be used as a gene source for gene therapy. Further disclosed are a replicable recombin-ant DNA which comprises a replicable expression vector and, operably inserted therein, the above-mentioned DNA; a cell of a microorganism or cell culture, which is transformed with the above-mentioned replicable recombinant DNA; a polypeptide of a dominant negative form of the above-mentioned MAPK kinase and a DNA coding for the same; and an antibody capable of binding specifically to the above-mentioned MAPK kinase. |
| priorityDate | 1997-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 857.