http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2286385-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1998-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05f8affe840cbe77f385346566f5efc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d9d496d7faa254c34a18f1b8b06195d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a24e0f21a9706320c50c9d3967c0d8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51a244be40f54e67d76446ff101f80d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed516a9768e0db737c86432feec1acaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c87f4505a428a94e7f439124fd18b2cc |
| publicationDate | 2011-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2286385-C |
| titleOfInvention | Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof |
| abstract | The quinoline derivatives have formula (I) in which: Ra, Rb and Rc, identical or different, represent one or more substituents, themselves identical or different, occupying any position on the wherein said substituents or substituents are selected from - (CH2) n -Y or -CH = CH-Y, where Y is halogen, -OH, -OR, -COH, -COR, -COOH, -COOR, -COH, -COR, -CONH2, -CON (Rx, Ry) -CH = NOH, -CO-CH = NOH, -NH2, -N (Rx, Ry), -NO2, -PO (OR) 2 -SH2, -SR, -SO2R, -SO2NHR, CN, or Z (Rc), where R is alkyl of 1 to 8 carbon, or aryl or heterocyclic, Rx and Ry, identical or different are alkyl of 1 to Carbon, Z an aryl or heterocycle and n is zero or an integer of 1 to 5, Rb may also represent a hydrogen, and when Y is -COOH or -COOR in Rc, Z, if it represents aryl, has at least 3 substituents or the quinoline ring is trisubstituted, X is an ethylenic double bond; a group - (CH2) n-, where n is an integer from 1 to 5: or a group -CH (Rd) -CH (Re), Rd and Re, identical or different, representing hydrogen, halogen, hydroxy or epoxy; or a group - (CH2) n ', -OC (O) - (CH2) m-, - (CH2) n, -C (O) -O- (CH2) m-, -(CH2) n, -O- (CH2) m-, - (CH2) n, -N (Q) - (CH2) m-, or - (CH2) n, -S (O) t- (CH2) m -, where n = 1 to 8, m = 0 to 8, t = 0.1 or 2, and Q = H, aryl or alkyl, as well as salts pharmaceutically acceptable derivatives of these derivatives, their diastereoisomeric forms and their enantiomeric forms. Application as effect medications HIV anti-integrase inhibitor. |
| priorityDate | 1997-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 171.