| abstract |
Cyclic analogues of histatin H-5, having from about 15 - 20 amino acid units exhibiting substantial identity to histatin H-5, and having a cyclic portion of from - 16 of the amino acid units, have been found to exhibit enhanced bio-activity against a variety of different microorganisms. The cyclic structure is imparted by replacement of naturally occurring amino acids in histatin-5 sequences by, for example, by cysteine units, so as to cause cyclization through formation of disulfide bridges. |