| abstract |
A compound of formula (I): (see formula I) wherein m, n, o, p, q, r are integers; A is O, NH or S; B is 0 or NH; D is O or NR9, wherein R9 is H or alkyl; E is CH2, 0, NH, or S(O)a, wherein a is 0, 1 or 2; R1 is H, optionally substituted alkyl or optionally substituted heterocycle; R2 and R3 may be taken together to form a carbonyl or cycloalkyl, or R2, R3 and R4 are independently H, OH, halo, CN, carboxy, nitro, or optionally substituted amino; R5 is a saturated or unsaturated cyclic or bicyclic (C3-C7) heterocyclic group; R6, R7 and R8 are each independently H, halo, carboxy, optionally substituted amino, nitro, hydroxy, optionally substituted alkyl, acyloxy, or heteroaryl, or R7 and R8 may be taken together to form a fused bicyclic ring, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, Crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS. |