| abstract |
4-Tetrahydropyridylpyrimidine derivatives of general formula (I); and medicinally acceptable salts thereof, wherein Ar is phenyl optionally substituted with one to three groups selected from among halogeno, C1-C5 alkyl, C1-C5 alkoxy and trifluoromethyl, thienyl or furanyl; R1 is hydrogen, C1-C5 alkyl or amino optionally substituted with one or two C1-C5 alkyl groups; R2 is C1-C5 alkyl, C4-C7 cycloalkylalkyl, C2-C5 alkenyl or C2-C5 alkynyl; and X1, X2 and X3 are each independently hydrogen, halogeno, C1-C5 alkyl, C1-C5 alkoxy, C1-C5 alkylthio or amino optionally substituted with one or two C1-C5 alkyl groups. These compounds are efficacious against diseases in which CRF is believed to be concerned, for example, melancholia, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, digestive diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immunologic diseases and so on. |