| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39c68430bcb778feae2ad4e9640ad0ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_604e07c32377cab416660b10fd8f494c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-645
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate |
1998-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec468b0facad26ceca1b61ac13c0b141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4bde436d69b83f8a2929519431bc374
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fa06d2edbe1a15fe391f923926ce572
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1914d07467999fb3ff5107e5e1cfb691 |
| publicationDate |
1998-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2278924-A1 |
| titleOfInvention |
Method and conjugate for treating h. pylori infection |
| abstract |
A method and conjugate for treating H. pylori infection in a subject are disclosed. The conjugate is composed of (a) a nuclease-resistant antisense oligomer effective to inhibit H. pylori infection in the subject by base-specific Watson-Crick binding to an H. pylori mRNA transcript, and (b) a transport moiety conjugated to the oligomer. The transport moiety is effective to facilitate uptake of the conjugate from the environment of the stomach into the cytoplasm of H. pylori cells by active transport or by pH-gradient transport across of the cell membrane of H. pylori. The conjugate is administered by oral route, preferably in a swellable polymer bolus designed to release the conjugate in sustained release. |
| priorityDate |
1997-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |