| abstract |
Compounds useful in the treatment of cyclooxygenase-2 mediated diseases are provided of formula (I): (see formula I) wherein R1 is selected from the group consisting of (a) S(O)2CH3, and (b) S(O)2NH2, and R2 is unsubstituted, mono or di- substituted phenyl wherein the substituents are selected from the group consisting of halo, methoxy, methyl, said halo being selected from the group consisting of fluoro, chloro and bromo; the compounds (I) are produced in a process of treating in a non-aqueous polar solvent a compound of formula (A) (see formula A) wherein R1 and R2 are as defined above, in the presence of a strong base; to yield said compound of formula (I). |