abstract |
The invention provides Gemcitabine esters or amides in which the 3'- and/or 5'- OH group and/or the N4-amino group is derivatised with a C18- and/or C20- saturated or mono-unsaturated aryl group, preferably an acyl group selected from oleoyl, elaidoyl, cis-icosenoyl and trans-eicosenoyl. The Gemcitabine esters and amides are useful as anti- cancer and anti-viral agents. |