http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2277011-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2613944636ab2fdf3f83ef2d4b304f0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7155 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 |
| filingDate | 1998-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74aeb2fd813cc7b806d97cce51d1371b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55c251ff0302346a66794ffba13222cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f723dff45f6cfa4a7f19fa4546ec60da |
| publicationDate | 1998-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2277011-A1 |
| titleOfInvention | Membrane-permeable derivatives converted intracellularly into active peptides |
| abstract | The present invention relates to membrane-permeable peptides which are intracellular agonists and/or antagonists of chemotactic factor receptors are rendered hydrophobic through acylation and acetoxymethylation of their amine and acid functional groups. The modified peptides of the present invention are loaded into cells. The acetoxymethyl esters are cleaved by non-specific esterases rendering the peptides active in the intracellular compartments of the cells. The effects of the introduction of transformed specific peptides corresponding to intracellular regions common to the major chemokine receptors are illustrated. These peptides completely inhibited chemotactic factor and chemokine-induced calcium mobilization. Furthermore, leukocytes of mice intravenously injected with these peptides failed to migrate towards chemokines(IL-8). |
| priorityDate | 1997-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.