| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8be6a6c990669567cc455d32b00535e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-721 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
1997-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4227a5ac05d5bb11964b8c78071d32c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdd6396bc3f5a04c3c2f77df6dca3a63 |
| publicationDate |
1998-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2272345-A1 |
| titleOfInvention |
Bmp-4 promoter and use thereof in screening of therapeutic agents for the prevention and/or treatment of osteoporosis |
| abstract |
The present invention relates to a human bone morphogenetic protein-4 (BMP-4) promoter region and fragments thereof, a vector comprising said promoter region and host cells comprising said promoter regions or vectors. The invention further relates to a method for the identification of therapeutic agents for use in the prevention and/or treatment of osteoporosis, wherein said method comprises the steps of: a) introducing into a cell a first expression vector comprising a BMP-4 promoter region or fragments thereof operably linked to a reporter gene, and a second expression vector comprising DNA encoding the estrogen receptor; b) contacting said cell with potential therapeutic agents; c) monitoring the expression of the protein encoded by the reported gene. |
| priorityDate |
1996-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |