| abstract |
Amide derivatives represented by general formula (I), or their salts and medicinal compositions containing these derivatives and pharmaceutically acceptable carriers, wherein each symbol has the following meaning: A: heteroarylene; X: a bond, O, S, -NR5-, -NR5 CO-, -NR5 CONH-, -NR5 SO2 - or -NR5 C(=NH)NH-; R1 : H, optionally substituted lower aryl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted cycloalkyl; R2a and R2b : being the same or different from each other and each representing H or lower alkyl; R3 : H or lower alkyl; R4a and R4b : being the same or different from each other and each representing H or OH, or R4a and R4b forming together =O or =N-O-lower alkyl; and R5 : H or lower alkyl. These compounds are useful as remedies for diabetes having an insulin secretion accelerating effect together with an insulin sensitivity increasing effect. |