http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2268866-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 1996-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ce528588d19a6aad057228defca753b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91a31ca309f5bc32447aaed5c7317a75 |
| publicationDate | 2005-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2268866-C |
| titleOfInvention | Substituted arylalkylamines as neurokinin antagonists |
| abstract | Compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof are disclosed, wherein: A1 is -CH2R6, -OR6, -N(R6)(R7), -S(O)e R13. -(C(R6)(R7)O-6-OR6, -(C(R6)(R7))1-6-N(R6)(R7) or -(C(R6)(R7))1-6-S(O)e R13 and A2 is H, or A1 and A2 together are =O, =C(R6)(R7), =NOR6 or =S; Q is phenyl, naphthyl, -SR6, -N(R6)(R7), -OR6 or heteroaryl; T is H, aryl, heterocycloalkyl, heteroaryl, cycloalkyl or bridged cycloalkyl; b is 0, 1 or 2; b1 is 1 or 2; X is a bond -C(O)-, -O-, -NR6-, -S(O)e-, -N(R6)C(O)-, -C(O)N(R6)-, -OC(O)NR6-,-OC(=S)NR6-, -N(R6)C(=S)O-,-C(=NOR6)-, -S(O)2N(R6)-, -N(R6)S(O)2-, -N(R6)C(O)O- or -OC(O)-; R6, R7, R8a, and R13 ar e H, alkyl, hydroxyalkyl, alkoxy alkyl, phenyl or benzyl; or R6 and R7, together with the nitrogen to which they are attached, form a ring; R9 and R9a independently are R6 or -OR6; Z is optionally substituted (II), wherein g is 0-3 and h is 1-4, provided the sum of h and g is 1-7; wherein the aryl, phenyl, benzyl, naphthyl, heterocycloalkyl and heteroaryl groups are optionally substituted. Methods o f treating asthma, cough, bronchospasm, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed. |
| priorityDate | 1996-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 137.