| abstract |
A compound which is a bis(acridinecarboxamide) or bis(phenazinecarboxamide) derivative of formula (I), wherein each X, which may be the same or differen t in a given molecule, is -CH= or -N= each of R1 to R4 which may be the same o r different, H, C1-C4 alkyl, OH, SH, NH2, C1-C4 alkoxy, aryloxy, NHR, N(R)2, S R, SO2R wherein R is C1-C4 alkyl, CF3, NO2 or halogen, or R1 and R2 together fo rm a methylenedioxy group; each of R5 and R6, which may be the same or differen t, is H or C1-C4 alkyl; Z is (CH2)n, (CH2)nO(CH2)n, (CH2)nN(R7) (CH2)n, (CH2)nN(R7) (CH2)mN(R7) (CH2)n or (CH2)nN(CH2CH2)2N(CH2)n wherein R7 is H or C1-C4 alkyl and n and m, which may be the same or different, are each an integer of 1 to 4; or a pharmaceutically acceptable acid addition salt or N- oxide thereof; has activity as an antitumour and antibacterial agent.</SDOAB > |