http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2267047-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 |
| filingDate | 1999-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c464d16670bc4449758f4c443b7f954 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_920177f67a2df2e5561d8b076d8cd860 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_125673220fc5406c78406ae7c0b8fd2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdf8e2c4918bfdff801104287c8298df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36700e103de1dcae3c964eb702a5c088 |
| publicationDate | 1999-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2267047-A1 |
| titleOfInvention | Derivatives of phenoxy acetic acid and phenoxymethyl tetrazole having antitumor activity |
| abstract | The present invention relates to the use derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole of formula (I) wherein: - the -O-C(R1)(R2)-(CH2)P A group can be in ortho, meta or para position; - A is selected from -COOH, -COO-(C1-C4)alkyl, -CN or a group of formula in which R' is hydrogen or (C1-C4)alkyl; or the group A-(CH2)P C(R1)(R2)- is selected from phenyl, benzyl or (indolyl)methyl, which may be subsituted by R4 groups; - p is 0, 1 or 2; - R1 and R2 are independently selected from hydrogen or (C1-C8)alkyl or they form, together with the carbon atom to which they are linked, a (C3-C7)cycloalkyl group; - R4 are from 0 to 2 substituents independently selected from chlorine, bromine, iodine, fluorine, linear or branched (C1-C8)alkyl, hydroxy, (C1-C4)alkoxy, (C1-C4)acyl groups; or the group in formula (I) is a naphtyl group which may be on its turn substituted by R4 groups; - n is an integer from 1 to 4; - m is 0 or 1; - B is selected from linear or branched C1-C10 alkyl, -CO-C(R3)=CH-R, -CH=C(R3)-CO-Ar, -CO-CH(R3)-CH2-R or -CO-CH(R3)-CH2-NR5R6 when m is 0 or is -CH=C(R3)-CO-Ar when m is 1; - R is selected from hydrogen, -Ar or -CO-Ar; - R3 is hydrogen or a (C1-C8)alkyl group; - R5 and R6 are independently a (C1-C4)alkyl group or they form, together with the nitrogen atom to which they are linked, a piperidino, piperazino, (C1-C8)alkylpiperazino, morpholino or thiomorpholino group; - Ar is a phenyl group which can be unsubstituted or substituted with from 1 to 3 groups independently selected from chlorine, bromine, iodine, fluorine, linear or branched (C1-C8)alkyl, hydroxy, (C1-C4)alkoxy, (C1-C4)acyl groups, stereoisomers thereof or salts thereof with pharmaceuticaly acceptable acids or basis, for the preparation of a medicament having MDM2 antagonistic activity, new compounds of the above formula, and pharmaceutical compositions containing at least one of those compounds. |
| priorityDate | 1998-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 151.