http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2264666-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 |
| filingDate | 1997-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25dcbbc3ba6c1827a4d364e7427cf734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72bf1091b261e280187a670ef08ac147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d9b81b5f0e7e52ac7fc90b6b42eb1e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b82ba2d090ee03ff2c4c01704f86c55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbd020e4f3502e0923617558abefe081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74a4833eebd2a08975d33d5c8b77f025 |
| publicationDate | 1998-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2264666-A1 |
| titleOfInvention | Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase |
| abstract | Novel tricyclic compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: one of a, b, c and d represents N or NR9 wherein R9 is O-, -CH3 or -(CH2)nCO2H wherein n is 1 to 3, and the remaining a, b, c and d groups represent CR1 or CR2; or each of a, b, c, and d are independently selected from CR1 or CR2; each R1 and each R2 is independently selected from H, halo, -CF3, -OR10, -COR10, -SR10, -S(O)tR11 (wherein t is 0, 1 or 2), -SCN, -N(R10)2, -NR10R11, -NO2, -OC(O)R10, -CO2R10, -OCO2R11, -CN, NHC(O)R10, -NHSO2R10, -CONHR10, -CONHCH2CH2OH, -NR10COOR11, -SR11C(O)OR11, SR11N(R75)2; y is 0 (zero) or 1; n is 0, 1, 2, 3, 4, 5 or 6; T is -CO-; -SO-; SO2-; or -CR30R31; Z represents alkyl, aryl, aralkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -OR40, -SR40, 1CR40R42, (i), (ii), -NR40R42, (iii). Pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human. |
| priorityDate | 1996-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.