http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2264486-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2243a54fef78f99c39546c86983fb218 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-315 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 1997-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_931884758c909231e98d0a427bff0e9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f157ac76224e2076e9ff9c76b829636 |
| publicationDate | 1998-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2264486-A1 |
| titleOfInvention | Non-iga fc binding forms of the group b streptococcal beta antigens |
| abstract | The invention relates to a mutant C.beta. protein comprising the amino acid sequence A-X1X2X3X4X5X6X7X8X9X10X11X12-B, wherein A comprises amino acids 1-164 of the sequence shown in Fig. 1 (SEQ ID NO: 2), B represents a sequence starting from amino acid 177 and terminating at an amino acid between residue 1094 and 1127, inclusive, of the sequence shown in Fig. 1 (SEQ ID NO: 2), and X1 - X12 are each selected independently from the group consisting of Ala, Val, Leu, Ile, Pro, Met, Phe, Trp, a bond, and the wild type amino acid found at the corresponding position of the sequence shown in Fig. 1 (SEQ ID NO: 2), wherein said amino acid positions are numbered from the first amino acid of the native amino acid sequence encoding said protein, with the proviso that at least one of X1 through X12, inclusive, is other than the wild type amino acid, and wherein the LPXTG motif may be missing from the mutant C.beta. protein. The invention also relates to a polynucleotide molecule encoding a mutant C.beta. protein, as well as vectors comprising such polynucleotide molecules, and host cells transformed therewith. The invention also relates to a conjugate comprising the mutant C.beta. protein covalently conjugated to a capsular polysaccharide. The invention also relates to a vaccine comprising at least one mutant C.beta. protein of the invention and a pharmaceutically acceptable carrier. The invention also relates to a method of inducing an immune response in an animal, comprising administering the vaccine of the invention to an animal in a therapeutically effective amount. |
| priorityDate | 1996-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 639.