abstract |
Phosphonate nucleotide compounds represented by general formula (I), their salts, hydrates and solvates thereof, and drugs containing the same, wherein R1 represents C1-6 alkyl, etc.; R2 represents hydrogen, halogenated C1-4 alkyl, etc.; R3 represents hydrogen, halogenated C1-4 alkyl, etc.; R4 represents hydrogen, halogenated C1-4 alkyl, etc.; and X represents carbon or nitrogen. These drugs are useful as antiviral agents for human immunodeficiency virus, herpes simplex virus, hepatitis B virus, etc., and as antitumor agents. |