http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2261811-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_700ff9a01db2075489cb7ed87392dc28 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S623-918 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S623-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S623-916 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S623-921 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3604 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36 |
| filingDate | 1997-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a9ced41210c2b4dbb41595269520d1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_267290541db082a54d10a1c6e4584fa6 |
| publicationDate | 2004-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2261811-C |
| titleOfInvention | Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods |
| abstract | Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate their propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and cross-linked by glutaraldehyde are exposed to a carboxyl activating agent to convert the free carboxyl (COOH) groups of the collagen molecules to activated carboxyl moieties (e.g., o-acylisourea). Thereafter, the collagenous tissue is exposed to a compound capable of reacting with the activated carboxyl moieties (e.g., o-acylisourea) to form non-carboxyl side groups. Monofunctional and multi-functional amines are examples of compounds which may be utilized to react with the activated carboxyl moieties to form such non-carboxyl side groups. Thereafter, the collagenous tissue is again exposed to glutaraldehyde. If the non-carboxyl side groups have functional amino groups (NH2), such additional exposure to glutaraldehyde will result in additional glutaraldehyde cross-linking of the collagen molecules and resultant improvement of durability. |
| priorityDate | 1996-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.