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publicationDate 1998-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2260818-A1
titleOfInvention High fidelity detection of nucleic acid differences by ligase detection reaction
abstract Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
priorityDate 1996-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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