| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5819d0705b09a0114e9e1681851442a8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-812 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 |
| filingDate |
1997-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b834773de33c97cb51e7d642f7fecc56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0175b3ee23ccedf9ed4e877a2b54333e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7210e227de896f6e2a5600a9f0b4a3ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18374239cbad5055ed37bb6133aee6b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e217410dac34da05294b29db93a120f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_778c21ecc36739f994479ea52a42a98a |
| publicationDate |
1998-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2259499-A1 |
| titleOfInvention |
Process for separating alpha-1-proteinase inhibitor from cohn fraction iv1 +iv4 paste |
| abstract |
The present invention is directed to a process for purifying alpha-1-PI. The process comprises providing an impure protein fraction which comprises alpha-1-PI. The impure protein fraction is suspended in an aqueous solution at pH 6. Insoluble proteins are recovered and resuspended in aqueous solution at pH 8,5. PEG is added to precipitate .alpha.-2 proteins. To the PEG supernatant precipitation, which comprises alpha-1-PI, is added ZnCl2 to precipitate crude alpha-1-PI. The crude alpha-1-PI is resolubilized and apllied to an anion-exchange medium. A fraction comprising alpha-1-PI is recovered from the anion-exchange medium. Alpha-1-PI purified by the process has a specific activity about 1.0 units/OD280. |
| priorityDate |
1996-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |