| abstract |
This invention relates to compounds having structural homology to a contiguous sequence of amino acids within the sequence representing residues 149-197 of the G protein of respiratory syncytial virus, in which a) no oligosaccharide is linked to potential serine, threonine or asparagine attachment sites; b) four cysteine residues are involved in disulphide linkages; and c) the pattern of disulphide linkage is Cys 173 linked to Cys 186, and Cys 176 linked to Cys 182, and in which said compounds possess a biological activity of respiratory syncytial virus G protein, and also encompass biologically-active peptidomimetic and other analogues of these compounds, and antibodies thereto. The compounds of the invention are useful as therapeutic, diagnostic, and screening agents in relation to Pneumoviruses, especially respiratory syncytial virus. |