| abstract |
The present invention relates to compounds of formula (I) that inhibit matrix metalloproteinases and to a method of inhibiting matrix metalloproteinases using the compounds, wherein Q is an un-natural amino acid. More particularly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal diseases, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disases dependent upon tissue invasion by leukocytes. |