| abstract |
Selected compounds of formula (I) in which: R1 is hydrogen or a corresponding pharmaceutically acceptable ester or a pharmaceutically acceptable salt thereof; R2 and R3 which may be the same or different is each selected from hydrogen or optionally substituted C(1-6)alkyl; X is a group X'(CH2)m in which X' is CO, CONR4, COO, CONR4CO, CONHO or CH2O in which R4 is hydrogen or C(1 6)alkyl and m is 0 or an integer from 1 to 12; or a C(1-12)alkylene chain optionally interrupted by X'; and Y is an optionally substituted aryl group; having the absolute configuration (4R,SS); are inhibitors of the enzyme LpPLA2 and thereof of use in treating atherosclerosis. |