| abstract |
Disclosed are compounds of formula (I) or the pharmaceutically acceptable ac id addition salts thereof wherein: R1, R2, R3, R4, R5, R6 and R7 independently represent hydrogen, halogen, hydroxy, alkyl, alkoxy, amino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, cyano, nitro, trifluoromethyl, or trifluoromethoxy; R8 is hydrogen or lower alkyl; X represents an optionally substituted alkylene group; and Y represents a mono-, di- or trisubstituted cyclic amino group, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which responds to dopaminergic blockade such as substance abuse and obsessive compulsive disoniers. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the us e of conventional neuroleptic agents. |