http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2250578-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37d372601438dc04dcea938f716473ac |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00 |
| filingDate | 1997-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89f2f67a162c5b94938280af4e5e26de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3048fd07b618255d32affa27feab267b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85c354fab8a71bfbfae443d49f24fd27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b29e8e9e87b308018e38421aa863d07 |
| publicationDate | 2003-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2250578-C |
| titleOfInvention | Improved chemical process for preparing amide derivatives of antibiotic a 40926 |
| abstract | Improved chemical process for preparing the compounds of formula (I), wherein: R1 represents (C9-C12)alkyl; M represents hydrogen, .alpha.-D-mannopyranosyl or 6-O-acetyl-.alpha.-D-mannopyranosyl and Y represents an amino group of formula -NR2-alk1-(NR3-alk2)p-(NR4-alk3)q-W. One aspect of the invention refers to the preparation of the intermediate compound of formula (III) (which corresponds to the above compound of formula (I) wherein R1 and M are as above defined and Y is hydroxy), by reacting a compound of formula (II) (which corresponds to the above compound of formula (I) wherein R1 and M are as above defined and Y is hydroxymethyl), with a (C1-C4)alkanol in the presence of a concentrated mineral acid, using the same alkanol as the reaction solvent and submitting the obtained ester compound to a reductive process by adding an alkali metal borohydride into the same reaction mixture. A further aspect of the invention refers to the amidation reaction for obtaining the compound of formula (I), which is carried out by reacting a compound of formula (III) with a suitable amine of formula (IV): NHR3-alk1-(NR4-alk2)p-(NR5-alk3)q-W, wherein R3, R4, R5, alk1, alk2, alk3, p, q and W are as defined in formula (I), in an inert organic solvent, in the presence of a condensing agent and setting the initial pH of the mixture (measured after diluting a sample of the reaction mixture with 9 volumes of water) at a value of from 6.5 to 9Ø By combining the above improved steps into a single process, it is possible to set up a particularly convenient process for preparing the compounds of formula (I). In addition, a purification method involving the use of polyamide resins and aqueous eluents is provided. |
| priorityDate | 1996-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.