| abstract |
The present invention relates to an isosorbide dinitrate-containing patch, in which an adhesive layer comprising an adhesive composition is formed on a flexible support, and the adhesive composition consists of an acrylic-based adhesive (A), a polyvinyl acetate-based adhesive (B), a plasticizing component (C) and isosorbide dinitrate (D), and satisfies the following weight ratios (1) through (3) of each of the components: (1) A:B = 70:30 to 10:90, (2) the weight ratio of the component C based on the adhesive composition is 10 to 40% by weight, and (3) the weight ratio of the component D based on the adhesive composition is 20 to 35% by weight. Provided is a patch excellent in percutaneous absorption, handleability, resistance to skin irritation, sustained release, adhesivity, etc. |