http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2246541-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b459ec3f5254c20ccd5ca24931c4610 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6dbc8af1157a8bba7d30d053437b371 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 1997-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d91a801a392cf0e83a9a2975859b25b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74a154a30a6d83e6622da07343ccad2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5b81490a5afc41e92262fdaeb437046 |
| publicationDate | 2005-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2246541-C |
| titleOfInvention | Intermediate for use in docetaxel synthesis and production method therefor |
| abstract | C7, C10 di-CBZ 10-deacetyl Baccatin III of formula (1) provides an intermediate for the production of docetaxel. A method of producing this C7, C10 di-CBZ 10-deacetyl Baccatin III is provided. Here, 10-deacetyl Baccatin III is acylated with at least 1.5 equivalents of n-butyl lithium and at least 1.5 equivalents of benzyl chloroformate in tetrahydrofuran. The 10-deacetyl Baccatin III may first be dissolved in tetrahydrofuran after which the n-butyl lithium is added followed by the addition of the benzyl chloroformate. The reaction is preferably at a reduced temperature of less than - 20 .degree.C. The resulting solution may be quenched with ammonium chloride and reduced to residue. The residue may then be redissolved in an organic solvent, washed, dried and recrystallized to purify the compound. |
| priorityDate | 1996-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.