http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2241094-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2773a2aeb05b5eabdf9e74906a9c5076 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1996-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_390c0f22542f4665c7adb454c35819d1 |
| publicationDate | 2006-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2241094-C |
| titleOfInvention | Tri-substituted phenyl derivatives useful as pde iv inhibitors |
| abstract | Compounds of general formula (I) are described wherein =W- is (1) =C(Y)-where Y is a halogen atom, or an alkyl or -XR a group where X is -O-, -S(O)p-[where p is zero or an integer of value 1 or 2], or -N(R b)- [where R b is a hydrogen atom or an optionally substituted alkyl group] and R a is a hydrogen atom or an optionally subtituted alkyl group or, (2) =N-; L is a -XR, [where R is an optionally substituted alkyl, alkenyl, cycloalkyl or cyloalkenyl group], -C(R11)=C(R1)(R2) or [-CH(R11)]n CH(R1)(R2) group where R11 is a hydrogen or a fluorine atom or a methyl group and R1 and R2, which may be the same or different, is each a hydrogen or fluorine atom or an optionally substitued alkyl, alkenyl, alkynyl, alkoxy alkylthio, -CO2R8, [where R8 is a hydrogen atom or an optionaly substituted alkyl, aralkyl, or aryl group], -CONR9R10 [where R9 and R10, which may be the same or different is each as defined for R8], -CSNR9R10, -CN or -NO2 group, or R1 and R2 together with the C atom to which they are attached are linked to form an optionally substituted cycloalkyl or cycloakenyl group and n is zero or the integer 1; R3 is a hydrogen or fluorine atom, an otionally substituted straight or branched alkyl group, or a hydroxyl group; and the remaining substituents are as defined in the description; and the salts, solvates, hydrates, prodrugs and N-oxides thereof. The compounds are phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present. |
| priorityDate | 1995-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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