| abstract |
The present invention provides a monoclonal anti-idiotype antibody 11D10 tha t elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derive d from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody I1D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment o f HMFG-associated tumors. |