http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2238656-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5cf811e10ad9068ddf72c04b69c8ba8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1241 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 1998-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_861d3b11d24a1ea92f0be28055275498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b6b9cfe6c9cc15c89030ea564201a79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa7bf75aa2815724fd410d9e47775343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f7c3810ef9f539ede6bcc247cdb265b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34c7c6673ae3ac51398e9d7e842f6420 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d84f562bc52d1b1a31f29ebf5940900f |
| publicationDate | 1999-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2238656-A1 |
| titleOfInvention | Mammalian staufen and use thereof |
| abstract | The present invention relates to mammalian staufen, a double-stranded RNA-binding protein involved in mRNA transport and localization. The invention further relates to the demonstration of the association of a RNA-binding protein with the rough endoplasmic reticulum (RER), implicating staufen and related proteins in the transport of RNA to its site of translation. Broadly, the invention therefore relates to transport and translation of RNA. More specifically, the present invention relates to human and mouse staufen proteins and to the modulation of transport of RNA to the RER by these proteins. The present invention also relates to isolated nucleic acid molecules encoding mammalian staufen, as well as vectors and host cells harboring same. In addition, the present invention relates to screening assays for identifying modulators of staufen activity and to the identification of mutants thereof which abrogate their interaction with RER. Furthermore, the present invention relates to the use of the double-stranded RNA binding activity of staufen as a means to target proteins into virions. The invention in addition relates to the incorporation of staufen into RNA viruses and the use of overexpression of staufen to significantly decrease the infectivity thereof. More particularly, the present invention relates to a novel and broad class of molecules which can be used as carriers to target molecules into virions of RNA viruses and to decrease infectivity of a wide variety of RNA viruses including retroviruses. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2003243788-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2003243788-B9 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7622257-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113096729-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1551855-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1551855-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8066972-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113096729-B |
| priorityDate | 1998-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 395.