| abstract |
Compounds of formula (I), wherein R1 is fluorine, hydroxy, (C1-5) alkox y, (C1-5) alkylthio, hydroxy(C1-5)alkoxy, a -NR10R11 group, cyano, (C1-5) alkylsulphonyl or (C1-5) alkylsulphinyl; R2 and R3 are each (C1-4) alkyl or, taken together with the nitrogen atom to which they are attached, form a saturated or unsaturated 5- to 10-membered heterocyclic radical optionally substituted one or more times by (C1-3) alkyl or (C1-3) alkoxy; each of R4, R5, R6, R7, R8 and R9 is independently hydrogen, halogen or trifluoromethyl, and when R1 is fluorine, R4, R5, R6, R 7, R8 and/or R9 may also be fluoromethyl; with the proviso that at least one of substituents R4 or R7 is other than hydrogen; each of R10 and R11 is independently hydrogen or (C1-5) alkyl, or R10 and R11, taken together with the nitrogen atom to which they are attached, form a heterocyclic radical selected from pyrrolidi n- 1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl optionally substituted by ( C1- 4) alkyl; a method for preparing same, and pharmaceutical compositions containi ng said compounds, are disclosed. Said compounds have very high affinity for central cannabinoid receptors. (see formula I) |