| abstract |
Benzenesulfonamide compounds of formula (I) (R1 is hydroxy, C1-4 alkoxy, NR6R7 (each R6 and R7 is, independently, H or C1-4 alkyl); R2 is H, C1-4 alkyl; R3, R4 are C1-4 alkyl, halogen, trifluoromethyl; R5 is H, C1-4 alkyl, halogen, trifluoromethyl; Y is cis-vinylene, trans-vinylene; and the symbol is single bond, double bond) can bind strongly to the EP1 receptor which is a prostaglandin E2 receptor subtype and scarcely bind to the other receptor subtypes. Therefore, they are considered to be useful as antipyretic agents, as analgesics or as agents for the prevention and/or treatment of pollakiuria having little side effect. |