http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2232267-C
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
filingDate | 1996-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2002-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb568b0ef468eb9db887f4904917f5f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aacc79a3f1231e7100f6b89dd2720a9a |
publicationDate | 2002-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-2232267-C |
titleOfInvention | Novel imidazole lipoxygenase inhibitors |
abstract | The present invention provides a compound of formula (I) and a pharmaceutically acceptable salt thereof, wherein Ar is phenylene optionally substituted with halo, hydroxy, cyano, amino, C1-C4 alkyl, C1-C4 alkoxy, C1- C4 alkylthio, C1-C4 halo-substituted alkyl or C1-C4 halo-substituted alkoxy; X is -A-X1- or -X1-A-, wherein A is a direct bond or C1-C4 alkylene, and X1 is ox y, thio, sulfinyl or sulfonyl; Ar1 is phenylene, pyridylene or thienylene optionally substituted with halo, hydroxy, cyano, nitro, amino, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 halo-substituted alkyl, C1-C4 halo- substituted alkoxy, C1-C4 alkylamino or di(C1-C4)alkylamino; Y is CN or CONR1R2 wherein R1 and R2 are independently hydrogen or C1-C4 alkyl; and R i s hydrogen or C1-C6 alkyl; W is C2-C3 alkylene, one carbon atom of which may b e replaced by an oxygen atom. Further the invention provides a pharmaceutical composition for treating an inflammatory disease, allergy or cardiovascular diseases or the like in a mammalian subject which comprises a compound of formula (I) and a pharmaceutically acceptable carrier. |
priorityDate | 1995-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.