| abstract |
Methods for enhancing the production of interferons in animal cell culture a re described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production, in particular cellular levels of double-stranded-RNA-dependent kinase (dsRNA-PKR, or PKR). In cell cultures that overproduce PKR, interferon synthesis is induced to high levels, and significant amount of interferon can be recovered without conventional induction of interferon by virus. |