http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2228828-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2de3beee83d9c19278da409b72c777a8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 |
| filingDate | 1998-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fedf88b663bc51b1d1e30b524fd8b47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ffc647dacb56be5ef6ab5579b5c33db |
| publicationDate | 1998-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2228828-A1 |
| titleOfInvention | Omega-cycloalkyl-prostaglandin e2 derivatives |
| abstract | .omega.-Cycloalkyl-prostaglandin E2 derivatives of formula (I) (see fig. I) wherein R is carboxy or hydroxymethyl; R1 is oxo, methylene or halogen atom; R2 is H, OH or C1-4 alkoxy; R3 is H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl substituted by 1-3 substituents selected from halogen atom, C1-4 alkoxy, C3-7 cycloalkyl, phenyl, and phenyl substituted by 1-3 substituents selected from halogen atom, C1-4 alkyl, C1-4 alkoxy, nitro and trifluoromethyl; n is 0-4; and non-toxic salts thereof, prodrugs thereof and cyclodextrin clathrates thereof strongly bind on the EP2 subtype receptor. Therefore, they are useful for prevention and/or treatment of immunological diseases (autoimmune diseases, organ transplantation, etc.), asthma, abnormal bone formation, neuronal cell death, liver damage, abortion, premature birth or retina neuropathy of glaucoma etc. |
| priorityDate | 1997-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 135.