http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2226880-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5cb1244155914156944230cbc8a0940f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-045 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 |
| filingDate | 1996-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e64befc511369e87c472abe4020abcf7 |
| publicationDate | 2007-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2226880-C |
| titleOfInvention | Cyclosporin derivatives with anti-hiv effect |
| abstract | The invention concerns new cyclic peptides of general formula (I) in which the letters A to K signify residues of the following amino acids: A a substituted homothreonine of the general formula (II): R1-CH2CH(CH3)-CH(OH)-CH(NHCH3)-COOH in which R1 is n-propyl or propenyl in which the double bond is preferably in the trans configuration, B .alpha.-aminobutyric acid, valine, norvaline or threonine, C a D-amino acid of the general formula (III): CH3NH-CH(R)-COOH in which R is straight-chain or branched-chain C2-C6 alkyl, alkenyl or alkinyl, whereby these groups may be substituted by hydroxy, amino, C1-C4 alkylamino, C1-C4 dialkylamino, alkoxy or acyloxy, COOR2 or CONHR2 in which R2 is straight-chain or branched-chain C1-C4 alkyl, X-R3 in which X is O or S and R3 is straight-chain or branched-chain C1-C4 alkyl, alkenyl or alkinyl and, when X is S, R3 may also be aryl or heteroaryl, halogen, preferably fluorine, cyano, CHR4R5 in which R4 is hydrogen, methyl, ethyl or phenyl and R5 is hydrogen, hydroxy, halogen (preferably fluorine), amino, C1-C4 alkylamino, C1-C4 dialkylamino, acyloxy (preferably acetyloxy), tert-butoxycarbonylamino-ethoxy-ethoxy-acetyloxy or alkoxycarbonyl (preferably butoxycarbonyl), D is N-methyl-gamma-hydroxyleucine or N-methyl-gamma-acetyloxyleucine, E is valine, F, I and J are each N-methylleucine, G is alanine, H is D-alanine or D-serine and K is N-methylvaline. The invention also concerns the preparation of such peptides and their use in the prevention of infection by the human immunodeficiency virus (HIV). |
| priorityDate | 1995-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 161.