| abstract |
A pharmaceutical compound of the formula: in which A is carboxy, tetrazolyl, -SO2H, -SO3H, -OSO3H, -CONHOH, or -P (OH)OR', -PO(OH)OR', -OPO(OH)OR' where R' is hydrogen, C1-6 alkyl, C2-6 alkenyl or optionally substituted phenyl-C1-6 alkyl, B is a bond, C1-6 alkylene or C2-6 alkenylene, R1 is hydrogen, hydroxyl, halo or group of the formula A-B-, X is C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene or C1-6 alkylene linked through -O-, -S- or -NR''- to Y, where R'' is hydrogen or C1-6 alkyl, and Y is (1) in which R2 and R3 are each halo, nitro, nitrile, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or optionally substituted phenyl, m and n are each 0 to 3, Q is -O-, -S-, -SO-, -SO2-, -CH=CH-, - (CH2)p-, -CONR' ' ' - or -NR' ' 'CO-, where p is 0 to 3 and R''' is hydrogen or C1-6 alkyl, and Z is or , or (2) in which R2, R3, m, n and Z are as defined above; provided that when Z is , X is C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and salts and esters thereof. |