http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2224411-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37555e87c88017b74fba94c8b8abbb42 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-215 |
| filingDate | 1996-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed5049420083c9dc6fbf84d90975d9ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbc8f08892cf51481d68ffc9d702cd6e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1f9d2204ad5418698cb272822df522a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abcacda5cd34ad78a879ee6db32c2a4d |
| publicationDate | 1997-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2224411-A1 |
| titleOfInvention | Novel farnesyl transferase inhibitors, preparation thereof and pharmaceutical compositions containing said inhibitors |
| abstract | New farnesyl transferase inhibitors of general formula (I), their preparation and pharmaceutical compositions containing them. In the general form (I), R1 represents YS-A1- (Y = hydrogen atom, remainder amino acid, fatty acid residue, alkyl or alkoxycarbonyl radical or a radical R4-S- in which R4 represents an alkyl radical containing 1 to 4 carbon atoms optionally substituted by a phenyl radical or a radical of general formula (II) in which A1, X, X1, Y1, R'1, R2, R'2 and R are defined as below, and A1 = alkylene radical containing 1 to 4 atoms of carbon optionally substituted in .alpha. of the grouping> C (X1) (Y1) by a amino or alkylamino, dialkylamino, alkanoylamino or alkoxycarbonylamino), X1 and Y1 each represents a hydrogen atom or together form with the carbon atom to which they are linked a group > C = O, R'1 represents hydrogen or an alkyl radical containing 1 to 6 atoms of carbon, X represents an oxygen or sulfur atom, R2 represents a alkyl, alkenyl or alkynyl radical containing 1 to 6 carbon atoms optionally substituted by hydroxy, alkoxy, mercapto, alkylthio, alkylsulfinyl or alkylsulfonyl, it being understood that when R2 represents a alkyl radical substituted by a hydroxy radical, R2 can form with the carboxy radical in .alpha. a lactone, R'2 represents hydrogen or a radical alkyl containing 1 to 6 carbon atoms, and R represents a hydrogen atom or an optionally substituted alkyl radical or a phenyl radical optionally substituted, it being understood that the radical (a) is in position -3 or -4 from the naphthyl nucleus. These new products have properties anticancer. |
| priorityDate | 1995-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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