| abstract |
Intermediate of the formula (X) (see fig.I) wherein Z is -OH or -HN2 and G" represents hydrogen, chloro, hydroxy or methoxy, provided that when Z is -OH, G" is not hydrogen, are employed in the manufacture of new phenylethanolaminomethyltetralins of formula (I) (see fig.II) wherein - E represents hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, phenyl, nitro, halogen or trifluoromethyl, - L represents hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, phenyl, nitro, or halogen, or - E and L taken together represent a group -CH=CH-CH=CH- or - CH2-CH2-CH2-CH2, and - G represent hydrogen, chloro hydroxy or an -OG' group wherein G' represents a (C1-C4) alkyl group either unsubstituted or substituted with hydroxy, (C1-C4) alkoxy, (C1-C4) alkoxycarbonyl, carboxy, or (C3-C7) cycloalkyl; a (C3-C7) cycloalkyl group; or a (C2-C4) alkanoyl group; and salts thereof. The compounds of formula I are active as intestinal motility modulating agents and intraocular hypertension lowering agents. |