| abstract |
The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: See formula I wherein R1 and R2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R4-O-N (wherein R4 represents hydrogen or substituted or unsubstituted lower alkyl); and R3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R3 are combined with each other to represent a single bond; Y represents R4B-O-N (wherein R4B has the same meaning as R4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects. |