| abstract |
The present invention provides processes for preparing compounds of formula (I), wherein R1 is -H, -OH, or OR3, in which R3 is a hydroxy protecting grou p; and R2 is -H, -OH, or OR4, in which R4 is a hydroxy protecting group, and fo r preparing compounds of formula (VII), wherein R1 is -H, -OH, or OR3, in whic h R3 is a hydroxy protecting group; R2 is -H, -OH, or OR4, in which R4 is a hydroxy protecting group; R5 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1- pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; R6 is bromo, chloro , iodo, or an activating ester group; and n is 2 or 3. Also provided are processes for preparing compounds of formula (VII) in addition to intermediates of formula (IX), wherein R1' is -OH, or -OR3, in which R3 is a hydroxy protecting group; and Z is bromo, iodo, triflate, or -B(OH)2.</SDOAB > |