| abstract |
This invention provides a compound of the following formula: (see fig. I) and the pharmaceutically acceptable salts thereof, wherein R is hydrogen, C1-C5 alkyl or an O-protecting group; B is a dircet bond, C1-C5 alkylene or C2-C5 alkenylene; R1 is C1-C5 alkyl, C2-C5 alkenyl or C3-C7 cycloalkyl-C1-C3 alkyl; R2is hydroxy or C1-C5 alkoxy; R3 is hydrogen, hydroxy or C1-C5 alkoxy; and R4 is hydrogen, phenyl or heteroaryl selected from furyl, thienyl and pyrrolyl, the phenyl and heteroaryl being optionally substituted by one to five substitutents selected from halo, hydroxy, C1-C3 alkyl, C1-C3 alkoxy and C2-C5 alkenyl. These compounds and pharmaceutical compositions containing such compounds are useful as analgesic, antiinflammatory, diuretic, anesthetic or neuroprotective agents, or an agent for stroke or treatment of functional bowel diseases such asabdominal pain, for the treatment of a mammalian subject, especially a human subject. |