| abstract |
The present invention relates to compounds of the general formula (see formula I) wherein X is -O-, -NH-, -CH2-, -CH=, -CO2-, -CONH-, -CON(lower alkyl)-, -S- and -SO2-; R1 - R4 are, independently from each other hydrogen, halogen, hydroxy, amino, nitro, lower-alkyl-sulfonylamido, 1- or 2-imidazolyl, 1-(1,2,4-triazolyl) or acetamido; R5, R6 are, independently from each other hydrogen, lower alkyl, hydroxy, lower alkoxy or oxo; R7-R10 are, independently from each other hydrogen, lower- alkyl, halogen, trifluoromethyl or lower-alkoxy; n is 0 or 1; and to pharmaceutically acceptable acid addition salts thereof. Compounds of the present invention are NMDA(N-methyl-D-aspartate)- receptor subtype selective blockers. |