| abstract |
An antibacterial or bactericide comprising a 2-aminothiazole derivative represented by general formula (I) or a salt thereof, wherein R1 and R2 represent each hydrogen, halogeno, lower alkyl, lower cycloalkyl, (un)substituted phenyl, thiophene, benzoyl, benzoylmethyl, optionally substituted benzyl, p-pivoloyloxyphenyl, -COOR3 (wherein R3 represents hydrogen or lower alkyl) or -CH2COOR4 (wherein R4 represents hydrogen, lower alkyl or optionally substituted benzyl); and A1 and A2 represent each hydrogen, lower alkanesulfonyl, halogenated lower alkanesulfonyl, optionally substituted phenyl, substituted benzoyl, substituted benzyl, (un)substituted benzenesulfonyl, (un)substituted lower alkanoyl, amidino, -CO-R5 (wherein R5 represents lower alkyl, optionally substituted phenyl, -(CH2)m-COOH (wherein m represents an integer of 1 to 5), -(CH2)n-NH-R6 (wherein n represents an integer of 1 to 5, and R6 represents hydrogen, tert-butoxycarbonyl or benzyloxycarbonyl) or -(CH2)Q-R7 (wherein Q represents an integer of 0 to 5, and R7 represents lower alkoxy, optionally substituted phenyl, optionally substituted pyridyl or cyclic amino), or A1 and A2 are combined with each other to represent cyclic amino. |