http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2205785-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 |
| filingDate | 1997-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d36243b1fad46e752be0a698abf9be20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c38f808a72b6c4d4546afdedb69fc7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55430b97f3fe0b0f7411e70d28c25250 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b93084abd07b7dcc940be09d8a94e23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a552fe5fa231c0ebe00bf592599fdf4 |
| publicationDate | 1997-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2205785-A1 |
| titleOfInvention | Sulfur-containing heterocyclic bradykinin antagonists, process for their preparation, and their use |
| abstract | Sulfur-containing heterocyclic bradykinin antagonists, process for their preparation, and their use Compounds of the formula I (see fig. I) in which one of the radicals X1, X2 or X3 is C-O-R2 and the other X1, X2, and X3, in each case, and X4, are then, identically or differently, N or CR1; R1 and R3 are, identically or differently, H, halogen, (C1-C6)-alkyl, O-R6, S-R6, NHR6, (C6-C12)-aryl, (C6-C12)-aryl-(C1-C3)-alkyl, C(O)-OR6, C(O)-H, (C2-C5)-alkenyl, NO2, SO3R7, CN or C(O)-NHR8, where alkyl, aryl and alkenyl can optionally be substituted; R2 is a compound of the formula (II) (see fig. II) R4 and R5 are, identically or differently, H, halogen, OR6, SR6, CN or (C1-C5)-alkyl; R6, R7 and R3 are, identically or differently, H, (C1-C5)-alkyl, (C3-C5)-alkenyl, (C6-C12)-aryl-(C1-C3)-alkyl, (C3-C10)-cycloalkyl, (C3-C10)-cycloalkyl-(C1-C3)-alkyl, C(O)-(O)0-1-(C1-C5)-alkyl or C(O)-(NH)0-1-(C1-C5)-alkyl; A is an aminocarboxylic acid; R9 is H, C(O)-(O)0-1-(C1-C5)-alkyl or C(O)-(O)0-1-(C1-C3)-alkyl-(C6-C10)aryl; R10 is -C(O)-D-E, -C(S)-D-E, -SO2-D-E or hydrogen; D is (C2-C5)-alkenediyl. (C1-C8)-alkanediyl, -(CH2)n-Yo-(CH2)m-, (C3-C10)-cycloalkanediyl, (C3-C10)-cycloalkyl-(C1-C3)-alkanediyl, (C3-C10)-cycloalkenediyl or (C3-C10)-cycloalkenyl-(C1-C3)-alkanediyl, which radicals can optionally be substituted; E is H, (C6-C10)-aryl or (C1-C9)-heteroaryl, which radical can optionally be substituted; Y is O, S or NR8; and the physiologically tolerated salts thereof, a process for their preparation, and their use as pharmaceuticals, are described. |
| priorityDate | 1996-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 238.